CIP2A signature reveals the MYC dependency of CIP2A-regulated phenotypes and its clinical association with breast cancer subtypes

@article{Niemel2012CIP2ASR,
  title={CIP2A signature reveals the MYC dependency of CIP2A-regulated phenotypes and its clinical association with breast cancer subtypes},
  author={Minna Niemel{\"a} and Otto Kauko and Harri Sihto and J-P Mpindi and Daniel Nicorici and Paula Pernil{\"a} and O. P. Kallioniemi and Heikki Joensuu and Sampsa Hautaniemi and Jukka Westermarck},
  journal={Oncogene},
  year={2012},
  volume={31},
  pages={4266-4278}
}
Protein phosphatase 2A (PP2A) is a critical human tumor-suppressor complex. A recently characterized PP2A inhibitor protein, namely cancerous inhibitor of PP2A (CIP2A), has been found to be overexpressed at a high frequency in most of the human cancer types. However, our understanding of gene expression programs regulated by CIP2A is almost absent. Moreover, clinical relevance of the CIP2A-regulated transcriptome has not been addressed thus far. Here, we report a high-confidence transcriptional… CONTINUE READING