CIL-102 interacts with microtubule polymerization and causes mitotic arrest following apoptosis in the human prostate cancer PC-3 cell line.

@article{Huang2005CIL102IW,
  title={CIL-102 interacts with microtubule polymerization and causes mitotic arrest following apoptosis in the human prostate cancer PC-3 cell line.},
  author={Yao-Ting Huang and D Y Huang and Jih-Hwa Guh and I-Li Chen and Cherng-Chyi Tzeng and C F Teng},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 4},
  pages={2771-9}
}
There have been no therapeutic agents that provide a survival advantage in hormone-refractory prostate cancer. Recently, the Food and Drug Administration approved docetaxel combined with prednisone for the treatment of patients with advanced metastatic prostate cancer, and it does show a survival benefit. Hence, anti-microtubule drugs might be of benefit in chemotherapy of hormone-refractory prostate cancer. We used metastatic hormone-refractory prostate cancer PC-3 cells to investigate… CONTINUE READING

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