CIKS/DDX3X interaction controls the stability of the Zc3h12a mRNA induced by IL-17.

  title={CIKS/DDX3X interaction controls the stability of the Zc3h12a mRNA induced by IL-17.},
  author={Domenico Somma and Paola Mastrovito and Marianeve Grieco and Alfonso Lavorgna and Angelica Pignalosa and Luigi Formisano and Anna Maria Salzano and Andrea Scaloni and Francesco Pacifico and Ulrich Siebenlist and Antonio Alessio Leonardi},
  journal={Journal of immunology},
  volume={194 7},
IL-17 is a proinflammatory cytokine that promotes the expression of different cytokines and chemokines via the induction of gene transcription and the posttranscriptional stabilization of mRNAs. In this study, we show that IL-17 increases the half-life of the Zc3h12a mRNA via interaction of the adaptor protein CIKS with the DEAD box protein DDX3X. IL-17 stimulation promotes the formation of a complex between CIKS and DDX3X, and this interaction requires the helicase domain of DDX3X but not its… CONTINUE READING
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