CIITA promoter I CARD-deficient mice express functional MHC class II genes in myeloid and lymphoid compartments

Abstract

Three distinct promoters control the master regulator of major histocompatibility complex (MHC) class II expression, class II transactivator (CIITA), in a cell type-specific manner. Promoter I (pI) CIITA, expressed primarily by dendritic cells (DCs) and macrophages, expresses a unique isoform that contains a caspase-recruitment domain (CARD). The activity… (More)
DOI: 10.1038/gene.2011.86

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