CIITA-driven MHC-II positive tumor cells: preventive vaccines and superior generators of antitumor CD4+ T lymphocytes for immunotherapy.

@article{Frangione2010CIITAdrivenMP,
  title={CIITA-driven MHC-II positive tumor cells: preventive vaccines and superior generators of antitumor CD4+ T lymphocytes for immunotherapy.},
  author={Valeria Frangione and Lorenzo Mortara and Patrizia Castellani and Andrea De Lerma Barbaro and Roberto S. Accolla},
  journal={International journal of cancer},
  year={2010},
  volume={127 7},
  pages={1614-24}
}
In our study, we have investigated whether tumors of distinct histological origin can be rejected if expressing CIITA-driven MHC class II molecules. Moreover, we assessed whether antitumor lymphocytes generated by this approach could be used as an immunotherapeutic tool for established cancers. Stable CIITA-transfectants of C51colon adenocarcinoma, RENCA renal adenocarcinoma, WEHI-164 sarcoma as well as TS/A mammary adenocarcinoma were generated. Tumor cells transfectants were injected in vivo… CONTINUE READING
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