CIITA and Its Dual Roles in MHC Gene Transcription

@inproceedings{Devaiah2013CIITAAI,
  title={CIITA and Its Dual Roles in MHC Gene Transcription},
  author={Ballachanda N. Devaiah and Dinah Singer},
  booktitle={Front. Immunol.},
  year={2013}
}
Class II transactivator (CIITA) is a transcriptional coactivator that regulates γ-interferon-activated transcription of Major Histocompatibility Complex (MHC) class I and II genes. As such, it plays a critical role in immune responses: CIITA deficiency results in aberrant MHC gene expression and consequently in autoimmune diseases such as Type II bare lymphocyte syndrome. Although CIITA does not bind DNA directly, it regulates MHC transcription in two distinct ways - as a transcriptional… CONTINUE READING
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Ciliary dyslexia candidate genes DYX1C1 and DCDC2 are regulated by Regulatory Factor X (RFX) transcription factors through X-box promoter motifs

FASEB journal : official publication of the Federation of American Societies for Experimental Biology • 2016
View 1 Excerpt

References

Publications referenced by this paper.
Showing 1-10 of 56 references

[Exploring the possibilities of hospital volunteers].

[Kango] Japanese journal of nursing • 1974
View 4 Excerpts
Highly Influenced

mastering the art of major histocompatibility complex expression

JA Harton, Ting JP. Class II transactivator
Mol Cell Biol • 2000
View 9 Excerpts
Highly Influenced

a newly discovered MHC class I transactivator (CITA)

TB Meissner, A Li, NLRC5 Kobayashi KS.
Microbes Infect (2012) 14(6):477–84. doi:10.1016/j.micinf. 2011.12.007 Conflict of Interest Statement: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Received: 24 October 20 • 2013
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