CIITA and Its Dual Roles in MHC Gene Transcription

  title={CIITA and Its Dual Roles in MHC Gene Transcription},
  author={Ballachanda N. Devaiah and Dinah Singer},
  booktitle={Front. Immunol.},
Class II transactivator (CIITA) is a transcriptional coactivator that regulates γ-interferon-activated transcription of Major Histocompatibility Complex (MHC) class I and II genes. As such, it plays a critical role in immune responses: CIITA deficiency results in aberrant MHC gene expression and consequently in autoimmune diseases such as Type II bare lymphocyte syndrome. Although CIITA does not bind DNA directly, it regulates MHC transcription in two distinct ways - as a transcriptional… CONTINUE READING
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