CIIA induces the epithelial-mesenchymal transition and cell invasion.

Abstract

Epithelial-mesenchymal transition (EMT) and the acquisition of invasive potential are key events in tumor progression. We now show that CIIA, originally identified as an anti-apoptotic protein, induces the EMT and promotes cell migration and invasion. Ectopic expression of CIIA induced down-regulation of E-cadherin and claudin-1 as well as up-regulation of… (More)
DOI: 10.1016/j.bbrc.2009.07.050

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