CII-DC-AdTRAIL cell gene therapy inhibits infiltration of CII-reactive T cells and CII-induced arthritis.

@article{Liu2003CIIDCAdTRAILCG,
  title={CII-DC-AdTRAIL cell gene therapy inhibits infiltration of CII-reactive T cells and CII-induced arthritis.},
  author={Zhongyu Liu and Xin Xu and H. -C. Hsu and Albert Tousson and Ping-Ar Yang and Qi Hui Wu and Cunren Liu and Shaohua Yu and Huang-ge Zhang and John D. Mountz},
  journal={The Journal of clinical investigation},
  year={2003},
  volume={112 9},
  pages={1332-41}
}
Previously, we described an APC-adenovirus (APC-Ad) FasL cell gene therapy method which could be used to deplete autoreactive T cells in vivo. FasL was toxic, however, and controlled regulation of FasL was not achieved. Here we describe an improved approach to delivering TNF-related apoptosis-inducing ligand (TRAIL) in vivo in which collagen II-induced (CII-induced) arthritis-susceptible (CIA-susceptible) DBA/1j mice were treated with CII-pulsed DCs that had been transfected with a novel Ad… CONTINUE READING