Corpus ID: 24052531

CI-1007, a dopamine partial agonist and potential antipsychotic agent. II. Neurophysiological and behavioral effects.

@article{Meltzer1995CI1007AD,
  title={CI-1007, a dopamine partial agonist and potential antipsychotic agent. II. Neurophysiological and behavioral effects.},
  author={L. Meltzer and C. Christoffersen and A. Corbin and F. W. Ninteman and K. Serpa and J. N. Wiley and L. Wise and T. Heffner},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1995},
  volume={274 2},
  pages={
          912-20
        }
}
  • L. Meltzer, C. Christoffersen, +5 authors T. Heffner
  • Published 1995
  • Chemistry, Medicine
  • The Journal of pharmacology and experimental therapeutics
  • CI-1007 has been described in receptor binding and biochemical tests as a dopamine (DA) partial agonist that exhibits DA autoreceptor agonist effects. The present studies describe the profile of CI-1007 in electrophysiological and behavioral tests. CI-1007 inhibited the firing of substantia nigra DA neurons with intrinsic DA agonist activity that was less than that of the full agonists apomorphine and talipexole but greater than that of the weak partial agonist SDZ 208-912. CI-1007 was more… CONTINUE READING
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