CHS 828, a novel pyridyl cyanoguanidine with potent antitumor activity in vitro and in vivo.

@article{Hjarnaa1999CHS8A,
  title={CHS 828, a novel pyridyl cyanoguanidine with potent antitumor activity in vitro and in vivo.},
  author={P J Hjarnaa and Elin Sporring Jonsson and Scilla Latini and Srijita Dhar and R. Larsson and Erik Bramm and Torsten Skov and Lise Binderup},
  journal={Cancer research},
  year={1999},
  volume={59 22},
  pages={
          5751-7
        }
}
A new class of recently discovered antineoplastic agents, the pyridyl cyanoguanidines, exert a potent antitumor activity in rodents after oral administration. Optimization in vitro and in vivo has resulted in the selection of the lead candidate CHS 828 (N-(6-chlorophenoxyhexyl)-N'cyano-N"-4-pyridylguanidine). CHS 828 was found to exert potent cytotoxic effects in human breast and lung cancer cell lines, with lesser effects on normal fibroblasts and endothelial cells. In a study using a panel of… CONTINUE READING

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