CHP2 activates the calcineurin/nuclear factor of activated T cells signaling pathway and enhances the oncogenic potential of HEK293 cells.

@article{Li2008CHP2AT,
  title={CHP2 activates the calcineurin/nuclear factor of activated T cells signaling pathway and enhances the oncogenic potential of HEK293 cells.},
  author={Guo-Dong Li and Xi Zhang and Rong Tao Li and Yue-dan Wang and Yan-Li Wang and Ke-jun Han and Xiao-ping Qian and Cheng-gang Yang and Ping Liu and Qun Wei and Wei-feng Chen and Jun Zhang and Yu Zhang},
  journal={The Journal of biological chemistry},
  year={2008},
  volume={283 47},
  pages={
          32660-8
        }
}
CHP2 (calcineurin B homologous protein 2) was initially identified as a tumor-associated antigen highly expressed in hepatocellular carcinoma. Its biological function remains largely unknown except for a potential role in transmembrane Na(+)/H(+) exchange. In the present study, we observed that ectopic expression of CHP2 promoted the proliferation of HEK293 cells, whereas knockdown of endogenous CHP2 expression in HepG2 inhibited cell proliferation. When inoculated into nude mice, CHP2… CONTINUE READING
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Nuclear accumulation of calcineurin B homologous protein 2 (CHP2) results in enhanced proliferation of tumor cells.

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