CHOP transcription factor phosphorylation by casein kinase 2 inhibits transcriptional activation.

@article{Ubeda2003CHOPTF,
  title={CHOP transcription factor phosphorylation by casein kinase 2 inhibits transcriptional activation.},
  author={M Gallego Ubeda and Joel Francis Habener},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 42},
  pages={40514-20}
}
The CAAT/enhancer binding protein homologous transcription factor CHOP, also known as GADD153, is involved in DNA damage, growth arrest, and the induction of apoptosis after endoplasmic reticulum stress and nutrient deprivation. CHOP dimerizes with and inhibits the binding of C/EBP-related transcription factors to their consensus DNA target sequences and also forms novel complexes with other transcriptional proteins (e.g. c-Jun, c-Fos). The transcriptional activation of these complexes is… CONTINUE READING

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