CHOP plays a pivotal role in the astrocyte death induced by oxygen and glucose deprivation.

@article{Benavides2005CHOPPA,
  title={CHOP plays a pivotal role in the astrocyte death induced by oxygen and glucose deprivation.},
  author={Amparo Benavides and Dolores Pastor and Pablo Santos and Pedro Tranque and Soledad Calvo},
  journal={Glia},
  year={2005},
  volume={52 4},
  pages={261-75}
}
Ischemia has different consequences on the survival of astrocytes and neurons. Thus, astrocytes show a remarkable resistance to short periods of ischemia that are well known to cause neuronal death. We have used a cell culture model of stroke, oxygen, and glucose deprivation (OGD), to clarify the mechanisms responsible for the exclusive resistance of astrocytes to ischemia. The expression of genes implicated in both ischemia-induced astrocyte death and post-ischemic survival was analysed by the… CONTINUE READING