CHOP-mediated hepcidin suppression modulates hepatic iron load.

Abstract

The liver is the central regulator of iron metabolism and accordingly, chronic liver diseases often lead to systemic iron overload due to diminished expression of the iron-regulatory hormone hepcidin. To study the largely unknown regulation of iron metabolism in the context of hepatic disease, we used two established models of chronic liver injury, ie… (More)
DOI: 10.1002/path.4221

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