CHOP and AP-1 cooperatively mediate PUMA expression during lipoapoptosis.

  title={CHOP and AP-1 cooperatively mediate PUMA expression during lipoapoptosis.},
  author={Sophie C. Cazanave and Nafisa A Elmi and Yuko Akazawa and Steven F. Bronk and Justin L Mott and Gregory J. Gores},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  volume={299 1},
Endoplasmic reticulum (ER) stress-mediated apoptosis is a key feature of hepatocyte cytotoxicity by saturated free fatty acids (FFA). This lipoapoptosis is dependent, in part, on the transcriptional upregulation of the BH3-only protein PUMA (p53 upregulated modulator of apoptosis). Although the activator protein (AP)-1 complex facilitates PUMA expression by saturated FFA, the transcription factor CAAT/enhancer binding homologous protein (CHOP) is also induced by ER stress and promotes apoptosis… CONTINUE READING