CHO mutant UV61 removes (6-4) photoproducts but not cyclobutane dimers.

@article{Thompson1989CHOMU,
  title={CHO mutant UV61 removes (6-4) photoproducts but not cyclobutane dimers.},
  author={Larry H. Thompson and David L. Mitchell and James D. Regan and Simon Bouffler and Sheila A. Stewart and W L Carrier and Rodney S. Nairn and Robert T. Johnson},
  journal={Mutagenesis},
  year={1989},
  volume={4 2},
  pages={
          140-6
        }
}
The CHO mutant UV61 was previously assigned to complementation group 6 of UV-sensitive rodent cell mutants. UV61 is less sensitive to killing by UV radiation than mutants such as UV5, which is highly defective in the incision process that acts on UV-induced lesions. The D37 for cell survival is approximately 4 J/m2 for UV61, compared with 10 J/m2 for the parental AA8 line and approximately 2 J/m2 for UV5. Similarly, mutation induction at the hprt and aprt loci shows an intermediate response to… CONTINUE READING

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