CHO cells expressing the human P₅-ATPase ATP13A2 are more sensitive to the toxic effects of herbicide paraquat.

@article{Pinto2012CHOCE,
  title={CHO cells expressing the human P₅-ATPase ATP13A2 are more sensitive to the toxic effects of herbicide paraquat.},
  author={Felicitas de Tezanos Pinto and Gerardo Raul Corradi and Diego Pablo de la Hera and Hugo Pedro Adamo},
  journal={Neurochemistry international},
  year={2012},
  volume={60 3},
  pages={243-8}
}
P-ATPases are membrane transporters energized by ATP. The subfamily of P₅-ATPases is the least studied P-ATPases and the ion substrate specificity of the P₅ subfamily is not known. Mutations of the human P₅ATPase gene ATP13A2 has been shown to underlie a form of Parkinson disease (PD). We investigated the link between ATP13A2 and environmental factors related to PD development. Increasing concentrations of the synthetic polyamine analog paraquat induced a greater cytotoxic effect over CHO cells… CONTINUE READING