CHM-1 induces apoptosis via p38-mediated upregulation of DR5 expression in human ovarian cancer SKOV3 cells.

@article{Lee2011CHM1IA,
  title={CHM-1 induces apoptosis via p38-mediated upregulation of DR5 expression in human ovarian cancer SKOV3 cells.},
  author={Jang-Chang Lee and Li-Chen Chou and Chi-Hung Huang and Jing-Gung Chung and Li‐Jiau Huang and Kuo Hsiung Lee and Mien-Chie Hung and Tzong-Der Way and Sheng-Chu Kuo},
  journal={European journal of pharmacology},
  year={2011},
  volume={670 1},
  pages={
          96-104
        }
}
Ovarian cancer is a leading cause of death due to neoplasm of the female genital tract. Treatment for advanced-stage disease remains limited, and an effective drug for ovarian cancer is urgently needed today. In the present study, MTT assay was used to evaluate the antiproliferative effect of the 2-(substituted phenyl)-6,7-methylenedioxyquinolin-4-one derivatives for developing new anti-ovarian cancer drugs. CHM-1 was the most active compound, and it exhibited potent antiproliferative activity… Expand
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