CHLORPROMAZINE AND PROTRIPTYLINE PHOTOTOXICITY: PHOTOSENSITIZED, OXYGEN INDEPENDENT RED CELL HEMOLYSIS

@article{Kochevar1979CHLORPROMAZINEAP,
  title={CHLORPROMAZINE AND PROTRIPTYLINE PHOTOTOXICITY: PHOTOSENSITIZED, OXYGEN INDEPENDENT RED CELL HEMOLYSIS},
  author={Irene E Kochevar and Angelo A Lamola},
  journal={Photochemistry and Photobiology},
  year={1979},
  volume={29}
}
Abstract—Red blood cell lysis photosensitized by chlorpromazine and protriptyline was investigated. Oxygen independent sensitized photohemolysis was observed with both compounds. When chlorpromazine and protriptyline were irradiated in the absence of red cells, both formed photoproducts which lysed red cells. These results indicate that chlorpromazine and protriptyline represent a new mechanistic class of phototoxic compounds which photosensitize membrane disruption by oxygen independent… Expand
Photobiochemistry in the dark: photohemolysis of red cells sensitized by chlorpromazine-bioenergized triplet acetone system.
  • Y. Makita, N. Durán
  • Chemistry, Medicine
  • Biochemical and biophysical research communications
  • 1979
TLDR
Experiments with external superoxide dismutase, catalase, benzoate and bicarbonate indicate the absence of O2•, H2O2 and OH· species as the precursor of the hemolytic effect of chlorpromazine. Expand
The photodynamic effect of chlorpromazine, promazine, and hematoporphyrin on lens protein.
  • J. Roberts
  • Biology, Medicine
  • Investigative ophthalmology & visual science
  • 1984
TLDR
Calf lens protein was irradiated with near ultraviolet (UV) light in the presence of the drugs chlorpromazine, promazine, and hematoporphyrin, suggesting that these photodynamic effects are due, at least in part, to a Type II mechanism. Expand
Phototoxicity mechanisms: chlorpromazine photosensitized damage to DNA and cell membranes.
  • K. Kochevar
  • Chemistry, Medicine
  • The Journal of investigative dermatology
  • 1981
TLDR
The mechanisms by which chlorpromazine photosensitizes damage to membranes, protein and DNA are described and compared to the mechanisms of photosensitization by psoralens, porphyrins, dyes, and other molecules. Expand
Possible mechanisms of toxicity due to photochemical products of protriptyline.
  • I. Kochevar
  • Chemistry, Medicine
  • Toxicology and applied pharmacology
  • 1980
TLDR
Photochemical studies demonstrated that the PTL photoproducts, which caused red blood cell lysis required water for their formation, were produced in higher yield in the absence of oxygen than in the presence of oxygen and were stable for at least 1 week. Expand
In vitro photosensitized lysis of red blood cells by an antifungal drug griseofulvin.
TLDR
Human red blood cells were lysed by in vitro irradiation in the presence of the antifungal drug griseofulvin and photohaemolysis was colloid osmotic in nature because it was preceded by K+ leakage from the cells and was delayed in the absence of 30 mM sucrose in the medium. Expand
INVESTIGATION OF PROTRIPTYLINE PHOTOPRODUCTS WHICH CAUSE CELL MEMBRANE DISRUPTION
TLDR
One of the photoproducts has been identified as a cyclobutyl photodimer of PTL based on its mass spectrum and UV absorption and its ability to undergo photore‐versal with 254 nm irradiation. Expand
Phototoxicity of chlorpromazine on retinal pigment epithelial cells.
TLDR
The phototoxic effects ofCPZ was found not to be due to stable photoproducts formed during irradiation of CPZ, and oxygen radical scavengers such as glutathione, B-carotene, mannitol, D-penicillamine as well as superoxide dismutase and catalase did not decrease cell lysis. Expand
Photohemolysis of human erythrocytes induced by aluminum phthalocyanine tetrasulfonate.
TLDR
The data suggest that photosensitization by AlPCS can cause membrane damage and that this damage may be responsible for cell killing. Expand
PHOTOPRODUCTS OF CHLORPROMAZINE WHICH CAUSE RED BLOOD CELL LYSIS
TLDR
Data indicate that the CPZ photoproducts which cause cell membrane disruption are dimers (Band B) and higher multimer (Band A) andHigher multimers of CPZ. Expand
Photolysis and photosensitized degradation of the diuretic drug acetazolamide
Abstract The phototoxic diuretic drug acetazolamide (1) is photolabile under irradiation with UV-B (at 300 nm) light in aerobic. Also photodegradation of 1 with UV-A light (at 337 nm, N2 laser) andExpand
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