CHLORAMPHENICOL USE AND CHILDHOOD LEUKAEMIA IN SHANGHAI

@article{Shu1987CHLORAMPHENICOLUA,
  title={CHLORAMPHENICOL USE AND CHILDHOOD LEUKAEMIA IN SHANGHAI},
  author={Xiao Ou Shu and Martha S. Linet and RuNie Gao and Yutang Gao and Louise A. Brinton and Fan Jin and Joseph F. Jr. Fraumeni},
  journal={The Lancet},
  year={1987},
  volume={330},
  pages={934-937}
}
A population-based case-control interview study of 309 childhood leukaemia cases and 618 age and sex matched controls showed a significant dose-response relation between chloramphenicol and risk of both acute lymphocytic leukaemia (ALL) and acute non-lymphocytic leukaemia (ANLL), treatment for more than 10 days being associated with risks of 11.0 and 12.0, respectively. A significant risk of ANLL was also observed with the use of syntomycin, a drug pharmacologically related to chloramphenicol… Expand
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