• DOI:10.1016/j.freeradbiomed.2019.04.037
Corpus ID: 143425389

CHK1-CENP B/MAD2 is associated with mild oxidative damage-induced sex chromosome aneuploidy of male mouse embryos during in vitro fertilization.

@article{Huang2019CHK1CENPBI,
  title={CHK1-CENP B/MAD2 is associated with mild oxidative damage-induced sex chromosome aneuploidy of male mouse embryos during in vitro fertilization.},
  author={Yue Huang and Siyao Ha and Z. Li and Jiena Li and W. Xiao},
  journal={Free radical biology & medicine},
  year={2019},
  volume={137},
  pages={
          181-193
        }
}

Yue Huang, Siyao Ha, +2 authors W. Xiao

Published 2019

Biology, Medicine

Free radical biology & medicine

A high incidence of aneuploidy is observed in vitro fertilization (IVF)-derived embryos, but the formation and repair mechanisms are unknown. Here, we investigated the effects of slightly increased reactive oxygen species (ROS) produced by in vitro culture conditions on embryo aneuploidy and the roles of the spindle assembly checkpoint (SAC) protein, mitotic arrest-deficient 2 (MAD2), and the DNA damage response (DDR) protein, checkpoint kinase 1 (CHK1), in aneuploidy repair. By assessing… CONTINUE READING

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