CHK1-CENP B/MAD2 is associated with mild oxidative damage-induced sex chromosome aneuploidy of male mouse embryos during in vitro fertilization.

@article{Huang2019CHK1CENPBI,
  title={CHK1-CENP B/MAD2 is associated with mild oxidative damage-induced sex chromosome aneuploidy of male mouse embryos during in vitro fertilization.},
  author={Yue Huang and Siyao Ha and Z. Li and Jiena Li and W. Xiao},
  journal={Free radical biology & medicine},
  year={2019},
  volume={137},
  pages={
          181-193
        }
}
  • Yue Huang, Siyao Ha, +2 authors W. Xiao
  • Published 2019
  • Biology, Medicine
  • Free radical biology & medicine
  • A high incidence of aneuploidy is observed in vitro fertilization (IVF)-derived embryos, but the formation and repair mechanisms are unknown. Here, we investigated the effects of slightly increased reactive oxygen species (ROS) produced by in vitro culture conditions on embryo aneuploidy and the roles of the spindle assembly checkpoint (SAC) protein, mitotic arrest-deficient 2 (MAD2), and the DNA damage response (DDR) protein, checkpoint kinase 1 (CHK1), in aneuploidy repair. By assessing… CONTINUE READING
    2 Citations
    AMPK Activity Contributes to G2 Arrest and DNA Damage Decrease via p53/p21 Pathways in Oxidatively Damaged Mouse Zygotes
    • 1
    • PDF

    References

    SHOWING 1-10 OF 52 REFERENCES
    Oxidative Stress Delays Prometaphase/Metaphase of the First Cleavage in Mouse Zygotes via the MAD2L1-Mediated Spindle Assembly Checkpoint
    • Q. Wu, Z. Li, +4 authors B. Wang
    • Medicine, Biology
    • Oxidative medicine and cellular longevity
    • 2017
    • 3
    • PDF