CHK negatively regulates Lyn kinase and suppresses pancreatic cancer cell invasion.

@article{Fu2006CHKNR,
  title={CHK negatively regulates Lyn kinase and suppresses pancreatic cancer cell invasion.},
  author={Yigong Fu and Radoslaw Zagozdzon and Ron Avraham and Hava Karsenty Avraham},
  journal={International journal of oncology},
  year={2006},
  volume={29 6},
  pages={1453-8}
}
Among the most important signaling pathways operating in pancreatic cancer cells are those resulting from mutations in the Ras oncogene or from overexpression of ErbB-2 and associated Src-family kinases. In this study, we aimed to characterize CHK expression and function in pancreatic cancer. Our data demonstrated CHK expression in human pancreatic cancer… CONTINUE READING