CHIP regulates leucine-rich repeat kinase-2 ubiquitination, degradation, and toxicity.


Mutation in leucine-rich repeat kinase-2 (LRRK2) is the most common cause of late-onset Parkinson's disease (PD). Although most cases of PD are sporadic, some are inherited, including those caused by LRRK2 mutations. Because these mutations may be associated with a toxic gain of function, controlling the expression of LRRK2 may decrease its cytotoxicity… (More)
DOI: 10.1073/pnas.0810123106