CHIP functions as a novel suppressor of tumour angiogenesis with prognostic significance in human gastric cancer.

@article{Wang2013CHIPFA,
  title={CHIP functions as a novel suppressor of tumour angiogenesis with prognostic significance in human gastric cancer.},
  author={Shouyu Wang and Xuming Wu and Jianbing Zhang and Yansu Chen and Jin Xu and Xiaowei Xia and Song He and Fulin Qiang and Aiping Li and Yongqian Shu and O. D. R\oe and Gang Li and Jianwei Zhou},
  journal={Gut},
  year={2013},
  volume={62 4},
  pages={496-508}
}
OBJECTIVE CHIP (carboxy terminus of Hsc70 interacting protein) is an E3 ubiquitin ligase that can induce ubiquitination and degradation of several tumour related proteins, and acts as a suppressor of tumour metastasis. This study explored the biological function and clinical significance of CHIP in gastric cancer (GC). METHODS The prognostic value of CHIP expression was evaluated using tissue microarray and immunohistochemical staining in two independent human GC cohorts. The role of CHIP on… CONTINUE READING