CHIF, a member of the FXYD protein family, is a regulator of Na,K-ATPase distinct from the gamma-subunit.

@article{Bguin2001CHIFAM,
  title={CHIF, a member of the FXYD protein family, is a regulator of Na,K-ATPase distinct from the gamma-subunit.},
  author={Pierre B{\'e}guin and Gilles Crambert and Saida Guennoun and Haim Garty and J D Horisberger and K{\"a}thi Geering},
  journal={The EMBO journal},
  year={2001},
  volume={20 15},
  pages={
          3993-4002
        }
}
The biological role of small membrane proteins of the new FXYD family is largely unknown. The best characterized FXYD protein is the gamma-subunit of the Na,K-ATPase (NKA) that modulates the Na,K-pump function in the kidney. Here, we report that, similarly to gamma(a) and gamma(b) splice variants, the FXYD protein CHIF (corticosteroid-induced factor) is a type I membrane protein which is associated with NKA in renal tissue, and modulates the Na,K-pump transport when expressed in Xenopus oocytes… CONTINUE READING

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