CHFR protein expression predicts outcomes to taxane-based first line therapy in metastatic NSCLC.

@article{Pillai2013CHFRPE,
  title={CHFR protein expression predicts outcomes to taxane-based first line therapy in metastatic NSCLC.},
  author={Rathi N. Pillai and Seth A Brodie and Gabriel L. Sica and You Shaojin and Ge Li and Dana C. Nickleach and Lixia Yuan and Vijay A. Varma and Dacian V Bonta and James G. Herman and Malcom V Brock and Maria J. A. Ribeiro and Suresh S Ramalingam and Taofeek K Owonikoko and Fadlo R. Khuri and Johann Christoph Brandes},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2013},
  volume={19 6},
  pages={1603-11}
}
PURPOSE Currently, there is no clinically validated test for the prediction of response to tubulin-targeting agents in non-small cell lung cancer (NSCLC). Here, we investigated the significance of nuclear expression of the mitotic checkpoint gene checkpoint with forkhead and ringfinger domains (CHFR) as predictor of response and overall survival with taxane-based first-line chemotherapy in advanced stage NSCLC. METHODS We studied a cohort of 41 patients (median age 63 years) with advanced… CONTINUE READING
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