CHF3381, a novel antinociceptive agent, attenuates capsaicin-induced pain in rats.

@article{Bassani2005CHF3381AN,
  title={CHF3381, a novel antinociceptive agent, attenuates capsaicin-induced pain in rats.},
  author={Franco Bassani and Marco Bergamaschi and Pier Tonino Bolzoni and Gino Villetti},
  journal={European journal of pharmacology},
  year={2005},
  volume={519 3},
  pages={231-6}
}
Here, we have examined the effect of the novel antinociceptive agent CHF3381 on the development of nocifensive behaviour as well as secondary mechanical allodynia and hyperalgesia induced by intraplantar injection of capsaicin in rats. Vehicle, CHF3381 or gabapentin were orally administered 1 h before capsaicin injection. The duration of nocifensive behaviour was measured during the first 5 min after capsaicin injection. Secondary mechanical allodynia and hyperalgesia were measured at 5 and 15… CONTINUE READING

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