author={Lowell O. Randall},
  journal={Journal of Biological Chemistry},
  • L. O. Randall
  • Published 1 July 1938
  • Chemistry
  • Journal of Biological Chemistry
Charting human subcortical maturation across the adult lifespan with in vivo 7 T MRI
This work provides a detailed account of 17 prominent subcortical structures, describing their approximate iron and myelin contents, morphometry, and their age-related changes across the normal adult lifespan, and shows that the locations of many structures shift across the lifespan.
Charting human subcortical maturation across the adult lifespan with in vivo 7 T MRI
The human subcortex comprises hundreds of unique structures. Subcortical functioning is crucial for behavior, and disrupted function is observed in common neurodegenerative diseases. Despite their
Biomarkers Identification and Disease Modeling using Multimodal Neuroimaging Approaches in Polyglutamine Diseases
A combination of different MRI and MRS techniques to identify robust biomarkers in HD and SCA and therapeutic approaches that hold promise in HD are presented, showing that imaging biomarkers have higher effect sizes than clinical scales.
Effects of magnetization transfer on T 1 contrast in human brain white matter
Simulation and inversion-recovery MRI measurements at 3T and 7T show that substantial measurement variability results from unintended and uncontrolled perturbation of the magnetization of MRI-invisible (1)H protons of lipids and macromolecules, which results in bi-exponential relaxation.
Bayesian image decomposition applied to relaxographic imaging
The method, Bayesian Image Decomposition, recovers individual tissue type magnetization recovery curves and their corresponding tissue‐specific relaxographic images (i.e. segmented images) from a series of inversion recovery images.
Error Analysis of a Quantitative Cerebral Blood Flow Measurement Using H215O Autoradiography and Positron Emission Tomography, with Respect to the Dispersion of the Input Function
The effect of the inaccuracy of the input function on CBF measured by the H152O autoradiographic method was investigated and an analytical correction employing an inverse Laplace transform was applied to clinical CBF studies, and the results were compared with those from the C15O2 steady-state inhalation method.
What is the Correct Value for the Brain-Blood Partition Coefficient for Water?
  • P. Herscovitch, M. Raichle
  • Chemistry, Mathematics
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
  • 1985
The currently accepted value for whole-brain Λ, 0.95–0.96 ml/g, calculated from brain and blood water content data, is incorrect because in the calculation, theBlood water content was not adjusted for the density of blood.
Effect of Ketamine on Human Neurochemistry in Posterior Cingulate Cortex: A Pilot Magnetic Resonance Spectroscopy Study at 3 Tesla
Despite the high sensitivity to detect between-session differences in glutamate and glutamine concentrations, the state-of-the-art single-voxel 3T sLASER 1H-MRS methodology optimized for reproducible measurements did not detect delayed glutamatergic responses to subanesthetic ketamine doses in PCC.
Monitoring the Neurotransmitter Response to Glycemic Changes Using an Advanced Magnetic Resonance Spectroscopy Protocol at 7T
An advanced MRS acquisition protocol that combines commercial 7T hardware, BaTiO3 dielectric padding, optical motion tracking, and dynamic frequency and B0 shim updates to ensure the acquisition of reproducibly high-quality data will allow robust mechanistic investigations of the primary neurotransmitters, Glu and GABA, under changing glycemic conditions.