CHD8 is an ATP-dependent chromatin remodeling factor that regulates beta-catenin target genes.

@article{Thompson2008CHD8IA,
  title={CHD8 is an ATP-dependent chromatin remodeling factor that regulates beta-catenin target genes.},
  author={Brandi A Thompson and V{\'e}ronique Tremblay and Grace Shou-Yean Lin and Daniel A. Bochar},
  journal={Molecular and cellular biology},
  year={2008},
  volume={28 12},
  pages={3894-904}
}
ATP-dependent chromatin remodeling by the CHD family of proteins plays an important role in the regulation of gene transcription. Here we report that full-length CHD8 interacts directly with beta-catenin and that CHD8 is also recruited specifically to the promoter regions of several beta-catenin-responsive genes. Our results indicate that CHD8 negatively regulates beta-catenin-targeted gene expression, since short hairpin RNA against CHD8 results in the activation of several beta-catenin target… CONTINUE READING

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Our results indicate that CHD8 negatively regulates beta - catenin - targeted gene expression , since short hairpin RNA against CHD8 results in the activation of several beta - catenin target genes .
Here we report that full - length CHD8 interacts directly with beta - catenin and that CHD8 is also recruited specifically to the promoter regions of several beta - catenin - responsive genes .
Here we report that full - length CHD8 interacts directly with beta - catenin and that CHD8 is also recruited specifically to the promoter regions of several beta - catenin - responsive genes .
Our results indicate that CHD8 negatively regulates beta - catenin - targeted gene expression , since short hairpin RNA against CHD8 results in the activation of several beta - catenin target genes .
chromatin remodelingProcess involves geneCHD8 gene
We also report the first demonstration of chromatin remodeling activity for a member of the CHD6 - 9 family of proteins , suggesting that CHD8 functions in transcription through the ATP - dependent modulation of chromatin structure .
CHD8 is an ATP - dependent chromatin remodeling factor that regulates beta - catenin target genes .
CateninsIs biochemical function of gene productbeta catenin
Our results indicate that CHD8 negatively regulates beta - catenin - targeted gene expression , since short hairpin RNA against CHD8 results in the activation of several beta - catenin target genes .
Our results indicate that CHD8 negatively regulates beta - catenin - targeted gene expression , since short hairpin RNA against CHD8 results in the activation of several beta - catenin target genes .
Here we report that full - length CHD8 interacts directly with beta - catenin and that CHD8 is also recruited specifically to the promoter regions of several beta - catenin - responsive genes .
Here we report that full - length CHD8 interacts directly with beta - catenin and that CHD8 is also recruited specifically to the promoter regions of several beta - catenin - responsive genes .
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