CHD8 haploinsufficiency results in autistic-like phenotypes in mice

@article{Katayama2016CHD8HR,
  title={CHD8 haploinsufficiency results in autistic-like phenotypes in mice},
  author={Yuta Katayama and Masaaki Nishiyama and Hirotaka Shoji and Yasuyuki Ohkawa and Atsuki Kawamura and Tetsuya Sato and Mikita Suyama and Toru Takumi and Tsuyoshi Miyakawa and Keiichi I Nakayama},
  journal={Nature},
  year={2016},
  volume={537},
  pages={675-679}
}
Autism spectrum disorder (ASD) comprises a range of neurodevelopmental disorders characterized by deficits in social interaction and communication as well as by restricted and repetitive behaviours. ASD has a strong genetic component with high heritability. Exome sequencing analysis has recently identified many de novo mutations in a variety of genes in… CONTINUE READING