CHD7 gene polymorphisms are associated with susceptibility to idiopathic scoliosis.

@article{Gao2007CHD7GP,
  title={CHD7 gene polymorphisms are associated with susceptibility to idiopathic scoliosis.},
  author={Xiaochong Gao and Derek Gordon and Dongping Zhang and Richard Browne and Cynthia Helms and Joseph Gillum and Samuel M. Weber and Shonn E Devroy and Saralove Swaney and Matthew B. Dobbs and Jose A. Morcuende and V. L. Sheffield and Michael Lovett and Anne M Bowcock and John Herring and Carol Wise},
  journal={American journal of human genetics},
  year={2007},
  volume={80 5},
  pages={957-65}
}
Idiopathic scoliosis (IS) is the most common spinal deformity in children, and its etiology is unknown. To refine the search for genes underlying IS susceptibility, we ascertained a new cohort of 52 families and conducted a follow-up study of genomewide scans that produced evidence of linkage and association with 8q12 loci (multipoint LOD 2.77; P=.0028). Further fine mapping in the region revealed significant evidence of disease-associated haplotypes (P<1.0 x 10-4) centering over exons 2-4 of… CONTINUE READING