CHD5 Downregulation Associated with Poor Prognosis in Epithelial Ovarian Cancer.

  title={CHD5 Downregulation Associated with Poor Prognosis in Epithelial Ovarian Cancer.},
  author={Raymond R Y Wong and Loucia Kit-Ying Chan and Teresa Tsang and Coral W S Lee and Tak Hong Cheung and So Fan Yim and Nelson Siu and Sophia N C Lee and Mei Yun Yu and Stephen S. C. Chim and Yick-fu Wong and Tony Kwok Hung Chung},
  journal={Gynecologic and obstetric investigation},
  volume={72 3},
BACKGROUND The CHD5 gene located on 1p36 encodes a protein-chromodomain helicase DNA-binding protein 5. CHD5 has been shown to be a tumor suppressor gene candidate. This study investigated the involvement of CHD5 in ovarian cancer and its clinicopathological significance. METHODS CHD5 expression in ovarian cancer and its counterpart were determined by quantitative RT-PCR. The correlation of CHD5 expression to clinicopathological features of the tumor was analyzed. RESULTS CHD5 expression… CONTINUE READING


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