CHD1L promotes hepatocellular carcinoma progression and metastasis in mice and is associated with these processes in human patients.

@article{Chen2010CHD1LPH,
  title={CHD1L promotes hepatocellular carcinoma progression and metastasis in mice and is associated with these processes in human patients.},
  author={Leilei Chen and Tim Hon Man Chan and Yun-fei Yuan and Liang Hu and Jun Huang and Stephanie Ma and Jian Wang and Sui-sui Dong and Kwan Ho Tang and Dan Xie and Yan Li and Xinyuan Guan},
  journal={The Journal of clinical investigation},
  year={2010},
  volume={120 4},
  pages={1178-91}
}
Chromodomain helicase/ATPase DNA binding protein 1-like gene (CHD1L) is a recently identified oncogene localized at 1q21, a frequently amplified region in hepatocellular carcinoma (HCC). To explore its oncogenic mechanisms, we set out to identify CHD1L-regulated genes using a chromatin immunoprecipitation-based (ChIP-based) cloning strategy in a human HCC cell line. We then further characterized 1 identified gene, ARHGEF9, which encodes a specific guanine nucleotide exchange factor (GEF) for… CONTINUE READING

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