CHCHD4 Regulates Intracellular Oxygenation and Perinuclear Distribution of Mitochondria

Abstract

Hypoxia is a characteristic of the tumor microenvironment and is known to contribute to tumor progression and treatment resistance. Hypoxia-inducible factor (HIF) dimeric transcription factors control the cellular response to reduced oxygenation by regulating the expression of genes involved in metabolic adaptation, cell motility, and survival. Alterations… (More)
DOI: 10.3389/fonc.2017.00071

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