CHCHD2 connects mitochondrial metabolism to apoptosis

  title={CHCHD2 connects mitochondrial metabolism to apoptosis},
  author={Yong Liu and Yanping Zhang},
  booktitle={Molecular & cellular oncology},
As the powerhouse of cells and gatekeeper for apoptosis, mitochondria control life and death. CHCHD2, a mitochondrial protein previously known to regulate metabolism, has recently been identified as an apoptosis inhibitor. New data suggest a model in which CHCHD2 performs a prosurvival function by acting as both a reactive oxygen species scavenger and BCL-XL activator. 

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Reactive oxygen species in cancer.

Free radical research • 2010
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