Corpus ID: 221312463

CHARACTERIZATION OF THE MACROMOLECULAR COMPLEX OF GRANZYME B WITH SERGLYCIN

@inproceedings{Raja2002CHARACTERIZATIONOT,
  title={CHARACTERIZATION OF THE MACROMOLECULAR COMPLEX OF GRANZYME B WITH SERGLYCIN},
  author={S. Raja and Baikun Wang and Mandakini Dantuluri and U. Desai and B. Demeler and Katharina Spiegel and S. Metkar and C. Froelich},
  year={2002}
}
We have recently shown that the physiological mediator of granule-mediated apoptosis is a macromolecular complex of granzymes and perforin complexed with the chondroitin-sulfate proteoglycan, serglycin (Metkar, S. S., Wang, B., Aguilar-Santelises, M., Raja, S. M., Uhlin-Hansen, L., Podack, E., Trapani, J. A., and Froelich, C. J. (2002) Immunity 16, 417– 428). We now report our biophysical studies establishing the nature of granzyme B-serglycin (GrBSG) complex. Dynamic laser light scattering… Expand
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