CHARACTERISTICS OF D‐GLUCOSAMINE UPTAKE BY RAT BRAIN SYNAPTOSOMES

@article{Tan1977CHARACTERISTICSOD,
  title={CHARACTERISTICS OF D‐GLUCOSAMINE UPTAKE BY RAT BRAIN SYNAPTOSOMES},
  author={C. H. Tan and Neal A. Peterson and E. Raghupathy},
  journal={Journal of Neurochemistry},
  year={1977},
  volume={29}
}
Abstract— The uptake of D‐glucosamine by rat brain synaptosomes is studied as a function of time, temperature and synaptosomal protein and substrate concentrations. The rate of D‐glucosamine uptake, after correcting for simple diffusion, obeys Michaelis‐Menten kinetics. The apparent kinetic constants for the uptake process are Km= 2.5 0.8 mm, Vmax= 3.7 ± 1.2 nmol/mg protein/min. D‐Glucose, D‐mannose, 2‐deoxy‐D‐glucose and 3‐0‐methyl‐o‐glucose are potent inhibitors of D‐glucosamine uptake. 2… Expand
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