CHAPTER 5 Kinetic and Thermodynamic Analysis of Ligand – Receptor Interactions : SPR Applications in Drug Development

@inproceedings{Mol2008CHAPTER5K,
  title={CHAPTER 5 Kinetic and Thermodynamic Analysis of Ligand – Receptor Interactions : SPR Applications in Drug Development},
  author={Nico J. de Mol and Marcel J. E. Fischer},
  year={2008}
}
Increasing evidence can be found that describing receptor ligand interactions in terms of a ‘‘lock-and-key’’ model is no longer adequate. Receptors can be regarded as part of a ‘‘molecular machinery’’, in which ligand binding forms a trigger to activate or deactivate the machinery. According to this view, it is no longer sufficient to know how the key fits into the lock, but we should also find out the mechanism with which the key opens and closes the lock. In other words, in drug design we… CONTINUE READING

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