CHAPTER 4 – Influence of the Immune System on Central Nervous System Gene Transfer

@inproceedings{Forsayeth2006CHAPTER4,
  title={CHAPTER 4 – Influence of the Immune System on Central Nervous System Gene Transfer},
  author={John R. Forsayeth},
  year={2006}
}
The brain relies on the innate immune system to defend it against a wide variety of pathogens. The principle mechanism by which this system operates is activation of complement in response to the presence of pathogen-associated molecular patterns or apoptotic-cell-associated molecular patterns. This ancient mechanism monitors the presence of abnormal antigens associated with pathogenic organisms, but can also recognize damaged neurons. The principle reactive cells are glia (astrocytes and… CONTINUE READING