CHAPTER 3 – HUMAN AND DROSOPHILA ABC PROTEINS

@inproceedings{Dean2003CHAPTER3,
  title={CHAPTER 3 – HUMAN AND DROSOPHILA ABC PROTEINS},
  author={Michael Dean and Andrey Rzhetsky and Rando Allikmets},
  year={2003}
}
The identification of the complete set of 48 human ABC genes has allowed a comprehensive phylogenetic analysis of the superfamily. The nomenclature of ABC transporters is in excellent agreement with the phylogenetic groups obtained. In particular, all major ABC transporter families are represented in the human tree by stable clusters with high bootstrap values. This analysis provides evidence for frequent domain duplication of ATP-binding domains in ABC transporters. In nearly all cases, both… CONTINUE READING

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