Corpus ID: 6396348

CHAPTER 10 Niacinamide : A Topical Vitamin with Wide-Ranging Skin Appearance Benefits

@inproceedings{Berson2013CHAPTER1N,
  title={CHAPTER 10 Niacinamide : A Topical Vitamin with Wide-Ranging Skin Appearance Benefits},
  author={Diane S. Berson and Rosemarie Osborne and John E Oblong and Tomohiro Hakozaki and Mary Beth Johnson and Donald Lynn Bissett},
  year={2013}
}
Niacinamide is vitamin B3, an essential nutrient. In the body, it is converted to the co-factors NADH and NADPH that are involved in many biochemical reactions. Dietary deficiency of this water-soluble member of the vitamin B family causes pellagra, a disease which includes dermatitis and red lesions. Pellagra caused thousands of deaths in the United States in the first half of the twentieth century, until simple dietary supplementation with this absorbable vitamin was found to cure the… Expand

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References

SHOWING 1-10 OF 19 REFERENCES
Topical niacinamide reduces yellowing, wrinkling, red blotchiness, and hyperpigmented spots in aging facial skin 1
TLDR
Niacinamide was well tolerated by the skin and provided significant improvements versus control in end points evaluated previously: fine lines/wrinkles, hyperpigmentation spots, texture, and red blotchiness. Expand
Niacinamide-containing facial moisturizer improves skin barrier and benefits subjects with rosacea.
TLDR
This randomized, investigator-blind, controlled observational study was designed to assess whether a niacinamide-containing facial moisturizer would improve the stratum corneum barrier and thus provide a clinical benefit to subjects with rosacea. Expand
Facilitating facial retinization through barrier improvement.
TLDR
Results show that improving stratum corneum barrier function before beginning topical tretinoin therapy and continuing use of a barrier-enhancing cosmetic moisturizer during therapy facilitates the early phase of facial retinization and augments the treatment response. Expand
4 Final Report on the Safety Assessment of Sodium Dehydroacetate and Dehydroacetic Acid
Sodium Dehydroacetate and Dehydroacetic Acid are used as preservatives in cosmetic formulations at concentrations of 1.0 percent or less. Both compounds are rapidly absorbed when administered orallyExpand
Oral nicotinamide reduces actinic keratoses in phase II double-blinded randomized controlled trials.
TLDR
These phase II studies aimed to determine whether oral nicotinamide, at different doses, reduced AKs in sun-damaged individuals, and whether this was the first pilot trial of oral Nicotinamide. Expand
Nicotinamide Prevents Ultraviolet Radiation‐induced Cellular Energy Loss
TLDR
Nicotinamide appears to exert its UV protective effects on the skin via its role in cellular energy pathways, and is found to prevent UV‐induced cellular ATP loss and protected againstUV‐induced glycolytic blockade. Expand
The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer
TLDR
There is a need for the development of skin lightening agents for Asian women and Niacinamide is a possible candidate. Expand
UV radiation-induced immunosuppression is greater in men and prevented by topical nicotinamide.
TLDR
Nicotinamide is a safe and inexpensive compound that could be added to sunscreens or after-sun lotions to improve protection from immunosuppression, with gene chip microarrays suggesting the mechanisms of protection may include alterations in complement, energy metabolism and apoptosis pathways. Expand
Reduction in the appearance of facial hyperpigmentation by topical N‐undecyl‐10‐enoyl‐l‐phenylalanine and its combination with niacinamide
TLDR
Two studies are conducted to determine if the combination of N‐undecyl‐10‐enoyl‐l‐phenylalanine and niacinamide, a reported alpha‐melanocyte‐stimulating hormone (MSH) receptor antagonist, is more effective than niacine alone in reducing facial hyperpigmentation. Expand
A randomized, controlled comparative study of the wrinkle reduction benefits of a cosmetic niacinamide/peptide/retinyl propionate product regimen vs. a prescription 0·02% tretinoin product regimen
TLDR
Tretinoin is considered the benchmark prescription topical therapy for improving fine facial wrinkles, but skin tolerance issues can affect patient compliance, and cosmetic antiwrinkle products are well tolerated but are generally presumed to be less efficacious. Expand
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