CHANGES IN SODIUM AND POTASSIUM IN HUMAN RED CELLS IN VIVO RELATED TO TREATMENT WITH DIGOXIN, TO HYPOKALEMIA, AND TO CELL DENSITY

@article{Astrup1974CHANGESIS,
  title={CHANGES IN SODIUM AND POTASSIUM IN HUMAN RED CELLS IN VIVO RELATED TO TREATMENT WITH DIGOXIN, TO HYPOKALEMIA, AND TO CELL DENSITY},
  author={Jens Astrup},
  journal={Annals of the New York Academy of Sciences},
  year={1974},
  volume={242}
}
  • J. Astrup
  • Published 1 November 1974
  • Biology
  • Annals of the New York Academy of Sciences
Human red cells are low-sodium and high-potassium cells. In vivo the sodium and potassium concentrations are maintained at a steady state by an active sodium outflux and potassium influx in balance with the leak fluxes of sodium and potassium in the opposite directions. This system has been especially well described in human red cells, and it follows from the kinetics of the sodium and potassium fluxes that an inhibition of active transport, o r an increase in membrane permeability for these… 
7 Citations

Relation between plasma and red-cell electrolyte concentrations and digoxin levels in children.

We determined alterations in plasma and red-cell electrolyte concentrations associated with digoxin administration in 11 children in heart failure, 24 nontoxic patients receiving maintenance digoxin

Relationship between red blood cell potassium and plasma digitoxin concentrations in intoxicated patients.

The duration of red blood cell K+ depletion could be predicted from two relative simple in vitro assays and since RBC K+ is a marker of the inhibition of Na+K+ ATPase by digitoxin, this method could be of use for the management of patients self-poisoned with digitalis.

Stimulation and Inhibition of the Na+, K+-Pump by Cardiac Glycosides

The inhibition of the Na+, K+-pump by cardiac glycosides is very well documented and the analysis of the mechanism of this inhibition which paralleled the study of the properties of Na+,K+-ATPase has allowed the mechanism to be described.

Effect of digoxin upon intracellular potassium in man.

The effect of digoxin upon intramuscular potassium was studied by use of whole body counting and biopsy technique and a significant decrease in TBK and MK and a decrease of QS2-index was found in both groups after digitalization.

The Digoxin Index 1966–1981 Part I

The computerized data base MEDLINE was used to search the literature and provide the citations, and references published in 1981 will appear as an addendum to Part III of this index.

References

SHOWING 1-10 OF 21 REFERENCES

Sodium and potassium in human red cells: variations among centrifuged cells.

  • J. Astrup
  • Biology
    Scandinavian journal of clinical and laboratory investigation
  • 1974
While the density-related changes were dominated by the cellular loss of potassium and water, the changes related to digoxin treatment and to hypokalaemia were characterized by an equimolar increase, respectively decrease, in red cell sodium and potassium concentrations (density unchanged).

The effects of chronic hypokalaemia, hyponatraemia, and acid-base alterations on erythrocyte sodium transport.

SUMMARY 1. Erythrocyte sodium concentration and fluxes were measured in patients with acid-base disturbances, hypokalaemia and hyponatraemia. Results were similar to those obtained with normal

Sodium Movements in the Human Red Blood Cell

  • J. R. Sachs
  • Biology
    The Journal of general physiology
  • 1970
Evidence has been obtained that the ouabain-inhibited Na outflux and Na influx in K-free solutions represent an exchange of Nac for Nao via the Na-K pump mechanism.

Effects of some monovalent anions on fluxes of Na and K, and on glucose metabolism of ouabain treated human red cells.

The present work deals with the effects of the anions Cl, Br, NO3, I, SCN, and HCO3 on Na and K fluxes, and on glucose metabolism of human red cells suspended in isotonic electrolyte media at 38d C

Abnormalities in the sodium pump of erythrocytes from patients with hyperthyroidism.

It is concluded that there is a depression of the activity of the sodium pump in the red cells of hyperthyroid subjects, which allows the resting intracellular sodium concentration to rise until a new steady state is reached.

Some differences in erythrocyte composition and uptake of radioactive potassium, sodium, chromate, and triiodothyronine associated with in vivo aging

Differences in chemical composition and uptake of tracer amounts of several radioactive substances were determined in populations of young and old human and rabbit erythrocytes which were separated

Human red cell sodium and potassium in metabolic alkalosis.

  • J. FunderJ. Wieth
  • Biology, Medicine
    Scandinavian journal of clinical and laboratory investigation
  • 1974
Erythrocyte sodium and potassium was studied in 26 patients with metabolic alkalosis and changes in erythrocytes from alkalotic patients are interpreted in the light of in vitro examinations of the effect of bicarbonate ions on the cation permeability of human ery Throcytes.

The Active Transport of Sodium by Ghosts of Human Red Blood Cells

  • J. Hoffman
  • Biology
    The Journal of general physiology
  • 1962
The characteristics of the outflux of this residual Na24 indicated that the ghost system closely resembles intact red cells, and certain other features of this ghost system are also discussed.

Cation exchange between cells and plasma of mammalian blood; methods and application to potassium exchange in human blood.

Results indicate that the exchange of potassium between cells and plasma of heparinized human blood has been studied in vitro using the radioactive isotope K(42) and is relatively insensitive to oxygenation or reduction of the hemoglobin, and to 1200 r of gamma radiation.