CGS 19755, a selective and competitive N-methyl-D-aspartate-type excitatory amino acid receptor antagonist.

@article{Lehmann1988CGS1A,
  title={CGS 19755, a selective and competitive N-methyl-D-aspartate-type excitatory amino acid receptor antagonist.},
  author={John C. Lehmann and Arthur J. Hutchison and Susan E. McPherson and Cesare G Mondadori and Madeleine Schmutz and Christopher M. Sinton and Cindy Tsai and Deborah E. Murphy and Douglas J. Steel and Michael Kelly Williams},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1988},
  volume={246 1},
  pages={
          65-75
        }
}
CGS 19755 (cis-4-phosphonomethyl-2-piperidine carboxylic acid) was found to be a potent, stereospecific inhibitor of N-methyl-D-aspartate (NMDA)-evoked, but not KCl-evoked, [3H] acetylcholine release from slices of the rat striatum. The concentration-response curve to NMDA was shifted to the right by CGS 19755 (pA2 = 5.94), suggesting a competitive interaction with NMDA-type receptors. CGS 19755 inhibited the binding of [3H]-3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid to NMDA-type… CONTINUE READING

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