CGRP and migraine: neurogenic inflammation revisited

  title={CGRP and migraine: neurogenic inflammation revisited},
  author={Pierangelo Geppetti and Jay Guido Capone and Marcello Trevisani and Paola Nicoletti and Giovanni Zagli and M. R. Tola},
  booktitle={The Journal of Headache and Pain},
For more than a century neurogenic inflammation has been proposed to have a role in various human diseases. The present review will cover the conceptual steps of the itinerary that has led to the conclusion that neurogenic inflammation is important in migraine. Of particular relevance for the object of this article is the observation that tachykin–independent neurogenic inflammatory responses are evident in rodents, but much less pronounced or absent in other mammal species, including man… CONTINUE READING


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