CGP 36742: the first orally active GABAB blocker improves the cognitive performance of mice, rats, and rhesus monkeys.

@article{Mondadori1993CGP3T,
  title={CGP 36742: the first orally active GABAB blocker improves the cognitive performance of mice, rats, and rhesus monkeys.},
  author={Cesare G Mondadori and Jens J{\"a}kel and Georges Preiswerk},
  journal={Behavioral and neural biology},
  year={1993},
  volume={60 1},
  pages={62-8}
}
The learning capacity of experimental animals in cognitive tests can be improved by blockade of the GABAB receptors. After treatment with the GABAB antagonist CGP 36742, mice performed better in a passive-avoidance test; rats did likewise in a partner-recognition test, and rhesus monkeys also in a "conditional spatial color" task. The effects demonstrated in these three different species and covering diverse manifestations of learning and memory give reason to hope that this new active… CONTINUE READING

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