CGK733 does not inhibit ATM or ATR kinase activity in H460 human lung cancer cells.

@article{Choi2011CGK733DN,
  title={CGK733 does not inhibit ATM or ATR kinase activity in H460 human lung cancer cells.},
  author={Serah Choi and Luis Ignacio Toledo and Oscar Fern{\'a}ndez-Capetillo and Christopher J. Bakkenist},
  journal={DNA repair},
  year={2011},
  volume={10 10},
  pages={1000-1; author reply 1002}
}
The purpose of this letter is to address the activity of CGK733, small molecule that was reported to inhibit both ATM and ATR inase activities and block checkpoint signaling with great selecivity [1]. This manuscript was retracted [2]. Nevertheless, CGK733 s marketed as an ATM and ATR kinase inhibitor and several anuscripts have reported that CGK733 has effects on human cells 3–7]. We have investigated the effects of CGK733 in cells exposed o either ionizing radiation (IR) or ultraviolet… CONTINUE READING