CGK733 does not inhibit ATM or ATR kinase activity in H460 human lung cancer cells.

@article{Choi2011CGK733DN,
  title={CGK733 does not inhibit ATM or ATR kinase activity in H460 human lung cancer cells.},
  author={Serah Choi and Luis Ignacio Toledo and {\'O}scar Fern{\'a}ndez-Capetillo and Christopher J. Bakkenist},
  journal={DNA repair},
  year={2011},
  volume={10 10},
  pages={
          1000-1; author reply 1002
        }
}
  • Serah Choi, Luis Ignacio Toledo, +1 author Christopher J. Bakkenist
  • Published 2011
  • Biology, Medicine
  • DNA repair
  • Dear Editor, The purpose of this letter is to address the activity of CGK733, a small molecule that was reported to inhibit both ATM and ATR kinase activities and block checkpoint signaling with great selectivity [1]. This manuscript was retracted [2]. Nevertheless, CGK733 is marketed as an ATM and ATR kinase inhibitor and several manuscripts have reported that CGK733 has effects on human cells [3–7]. We have investigated the effects of CGK733 in cells exposed to either ionizing radiation… CONTINUE READING

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