CGG repeats associated with DNA instability and chromosome fragility form structures that block DNA synthesis in vitro.

@article{Usdin1995CGGRA,
  title={CGG repeats associated with DNA instability and chromosome fragility form structures that block DNA synthesis in vitro.},
  author={Karen Usdin and Kerry J Woodford},
  journal={Nucleic acids research},
  year={1995},
  volume={23 20},
  pages={4202-9}
}
A large increase in the length of a CGG tandem array is associated with a number of triplet expansion diseases, including fragile X syndrome, the most common cause of heritable mental retardation in humans. Expansion results in the appearance of a fragile site on the X chromosome in the region of the CGG array. We show here that CGG repeats readily form a series of barriers to DNA synthesis in vitro. There barriers form only when the (CGG)n strand is used as the template, are K(+)-dependent… CONTINUE READING