CFTR-mediated halide transport in phagosomes of human neutrophils.

@article{Painter2010CFTRmediatedHT,
  title={CFTR-mediated halide transport in phagosomes of human neutrophils.},
  author={Richard G. Painter and Luis Marrero and Gisele A Lombard and Vincent G. Valentine and William M Nauseef and Guoshun Wang},
  journal={Journal of leukocyte biology},
  year={2010},
  volume={87 5},
  pages={933-42}
}
Chloride serves as a critical component of innate host defense against infection, providing the substrate for MPO-catalyzed production of HOCl in the phagosome of human neutrophils. Here, we used halide-specific fluorescent sensors covalently coupled to zymosan particles to investigate the kinetics of chloride and iodide transport in phagosomes of human neutrophils. Using the self-ratioable fluorescent probe specific for chloride anion, we measured chloride dynamics within phagosomes in… CONTINUE READING