CFTR involvement in nasal potential differences in mice and pigs studied using a thiazolidinone CFTR inhibitor.

@article{Salinas2004CFTRII,
  title={CFTR involvement in nasal potential differences in mice and pigs studied using a thiazolidinone CFTR inhibitor.},
  author={Danieli B Salinas and Nicoletta Pedemonte and Chatchai Muanprasat and Walter F Finkbeiner and Dennis W. Nielson and Alan S. Verkman},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2004},
  volume={287 5},
  pages={L936-43}
}
Nasal potential difference (PD) measurements have been used to demonstrate defective CFTR function in cystic fibrosis (CF) and to evaluate potential CF therapies. We used the selective thiazolidinone CFTR inhibitor CFTR(inh)-172 to define the involvement of CFTR in nasal PD changes in mice and pigs. In normal mice infused intranasally with a physiological saline solution containing amiloride, nasal PD was -4.7 +/- 0.7 mV, hyperpolarizing by 15 +/- 1 mV after a low-Cl- solution, and a further 3… CONTINUE READING

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