CFTR function and prospects for therapy.

@article{Riordan2008CFTRFA,
  title={CFTR function and prospects for therapy.},
  author={John R. Riordan},
  journal={Annual review of biochemistry},
  year={2008},
  volume={77},
  pages={701-26}
}
Mutations in the gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) epithelial anion channel cause cystic fibrosis (CF). The multidomain integral membrane glycoprotein, a member of the adenine nucleotide-binding cassette (ABC) transporter family, conserved in metazoan salt-transporting tissues, is required to control ion and fluid homeostasis on epithelial surfaces. This review considers different therapeutic strategies that have arisen from knowledge of CFTR… CONTINUE READING
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